Which Pokémon is Pokémon: The First Movie about?

Mewtwo. Hence the subtitle, Mewtwo Strikes Back.

That was easy, wasn't it. Now try the hard ones. Click on the dot to see the answer.

In what TV series episode does Mewtwo first appear?

Mewtwo appears in The Battle of the Badge and in It's Mr. Mime Time. However, a carving of Mewtwo appears on the door to Bill's lighthouse in the much earlier episode Mystery at the Lighthouse. (This is odd, since Mewtwo's existence had been kept secret.)

Where does Gary appear in the movie?

Gary appears from behind in an early scene in which Giovanni is training Mewtwo. The audience does not see his face. However, the same scene appears in more detail in the TV episode, The Battle of the Badge.

On what literary work is the Mewtwo story based?

Although it's not official, the story shares common themes with Mary Shelley's Frankenstein in which a scientist artificially creates a human being who then turns against his creator.